Alloxan induced anti diabetic activity of boerhaavia diffusa pdf

After oral administration of each mesc singly or repeatedly to alloxan. An ethanolic extract of boerhaavia diffusa was found to reduce blood sugar in streptozotocin induced diabetic rats. The plant boerhaavia diffusa nyctaginaceae frequently known as punarnava 47. Seasonal variation in the medicine activities of boerhaavia diffusa punarnava and convolvuluspluricaulis shankhapushpi. Hypercholesterolemia and hypertriglyceridemia have been reported to occur in alloxan. An overview on antidiabetic medicinal plants having.

Anti diabetic effect was evaluated in alloxan induced diabetic model 2023. Indian science congress association proceedings 60, 699. The purpose of this study was to investigate the effects of daily oral administration of aqueous solution of boerhaavia diffusa l. The alcoholic and aqueous extract of luffa aegyptica was studied for antidiabetic activity in alloxan induced diabetic rats by oral. Punarnava, the anticancer and antidiabetic weeds v for. The increased activity of hexokinase can cause increased glycolysis and increased utilization of glucose for energy production. Effect of chronic administration of boerhaavia diffusa linn. We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. The antoxident activity was observed due to presence of minerals. Boerhaavia diffusa is an herb found in ayurveda and other traditional medicines. The present study was aimed to evaluate the anti diabetic activity potential of boerhaavia diffusa roots against streptozotocin stz induced experimental rats. Different doses of ethanolic fraction of ribes nigrum fruit were evaluated for hypoglycemic activity in alloxan induced diabetic rats. The antidiabetic activity of the chloroform extract of the plant leaves on chronic treatment of streptozotocin induced niddm non insulin dependent diabetes mellitus model diabetic rats was evaluated and the herb possesses antidiabetic activity.

The blood glucose lowering activity of the leaf extract was studied in streptozotocin. Many herbs and spices are known to be antihyperglycemic. Studies are in progress in our laboratory to elucidate the active components responsible for the blood sugar lowering effect in experimental diabetes. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal, intravenous and. A significant decrease in blood glucose and significant increase in plasma insulin levels were observed in normal and diabetic rats treated. Historically, boerhaavia diffusa has been used for its anti diabetic and diuretic properties. Punarnava, the anti cancer and antidiabetic weeds march 21, 20 punarnava, or known as boerhaavia diffusa linn. There was a significant delay in the onset of convulsions and reduction in mortality at all the three doses of crude extract fraction 1, 1500 and 2000 mg k in ptz model, as compared with vehicle control group. In the present study activities of liver enzymes such as glucokinase, glucose 6 phosphatase and fructose 1 6diphosphatase were also determined. Diabetes was induced in wistar rats by single intraperitoneal administration of alloxan monohydrate 150 mgkg.

In such circumstances, herbal medicines for the treatment of diabetes become significant. Antidiabetic activity of boerhaavia diffusa l effect on. In thioacetamide intoxicated rats, boerhaavia 2 mlkg root exhibited hepatoprotective activity as visible by protection of a majority of serum parameters, i. The herb mainly acts by reducing blood glucose level and. The present study was designed to evaluate the antioxidant activity of an aqueous boerhavia diffusa leaf extract blet 200 mgkg in rats with alloxan induced diabetes mellitus. Alloxan induced hyperglycemic male wistar rats were orally administered. The present study was undertaken to investigate the antihyperglycemic and antihyperlipidemic effects of ethanol extract of plectranthus amboinicus in normal and alloxan induced diabetic rats. The present study was proposed to assess the in vitro free radicalscavenging activity of b.

The present study was designed to evaluate the antioxidant activity of an aqueous boerhavia diffusa leaf extract blet 200 mgkg in rats with alloxaninduced diabetes mellitus. Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. In different areas of the world, boerhaavia diffusa has also been used for pain relief, anti. Anti diabetic activity of feronia limonia and artocarpus heterophyllus in streptozotocin induced diabetic rats. In the antidiabetic activity, the effects of boerhaavia diffusa aque.

Alloxan diabetes and streptozotocin diabetes figure 1 shows a schematic diagram of the tetraphasic and triphasic blood glucose responses induced by alloxan and streptozotocin, respectively, when injected 22. Mcp was orally administered once a day after 3 days of alloxan induction at 100, 200 and 300 mgkg body weight for 28 day. Its leaf extract has hypoglycemic effects9 in the present communication, the effects of b. The activity of this enzyme decreased in the liver of alloxan diabetic rats. Antihyperglycaemic and renoprotective effect of boerhaavia. The mechanisms of alloxan and streptozotocininduced. Alloxan, sometimes referred to as alloxan hydrate, refers to the organic compound with the formula ocnhco 2 coh 2. Chude and coworkers showed nondosedependent reduction in sugar levels in alloxan induced diabetic rats upon administration of aqueous extract of leaf of bd. It is better to standardize it first by jain et al. Antihyperglycemic activity of boerhaavia diffusa in. The present study was planned to elucidate hypoglycemic effect of essential oil of citrus reticulata and its interaction with glibenclamide in hyperglycemic rats.

They also exhibit a variety of biological activities. Evaluation of antidiabetic activity of a herbal formulation. The family of boerhaavia diffusa is nyctaginaceae 46. This medicinal plant distributed in tropical region such as south america, india and africa. Boerhaavia diffusa nyctaginaceae chloroform extracts of leaves of boerhaavia diffusa showed antidiabetic activity in streptozotocin induced diabetic rats which mainly act by reducing blood glucose level and increasing insulin sensitivity. Boerhaavia diffusa is a plant of tropical region used in ayurvedic as well as some other traditional herbal medicines taken for pain relief, anti inflammation, and treating indigestion. Hypoglycaemic and antidiabetic activity of stem bark. Anti diabetic effect of morinda lucida stem bark extracts on alloxan induced diabetic rats. Antihyperglycaemic and renoprotective effects of ethanolic extracts of b. In conclusion, the aqueous extract of boerhaavia diffusa leaves were found to exhibit a significant hypoglycemic and antihyperglycemic activity in normal and alloxan diabetic rats. In the present study, the essential oil of citrus reticulata is investigated for anti diabetic activity. Antidiabetic activity of the leaves extracts of wrightia. Boerhaavia diffusa supplement health benefits, dosage. Antidiabetic potential of murraya koenigii roots in.

Antihyperglycemic activity of the leaves of tetracera scandens linn. It is also used for its anti diabetic and diuretic properties. The protective action of this sugar is, however, strongly glucose and alloxan dosedependent. Study investigating the effect of oral administration of an aqueous solution of b. Antidiabetic activity of methanolic extract of grape seeds in alloxan induced diabetic rats maraia f elmhdwi1, naema m saed elaali1, nura n mohamed2, mona a muktar3 and negia b buzgeia4 1department of chemistry, faculty of science, benghazi university, libya 2department of medical biochemistry, faculty of medicine, benghazi university, libya 3department of chemistry, faculty of. The responses are accompanied by corresponding inverse changes in. The mechanism of alloxan and streptozotocin action in b. A watersoluble polysaccharide mcp was isolated from the fruits of momordica charantia l. Antidiabetic activity of boerhaavia diffusa l effect on hepatic key enzymes in experimental diabetes. Sir, we read with interest the article titled anomalies in alloxan induced diabetic model. Antidiabetic activity of methanolic extract of grape. Alloxaninduced diabetes, a common model for evaluating. Administration of blet to alloxan induced rats resulted in an increased activity of liver hexokinase. Antidiabetic activity of vinca rosea extracts in alloxan.

Antidiabetic activity on ethanolic extracts of fruits of. Phytochemical, therapeutic, and ethnopharmacological. The present study was designed to investigate the antihyperlipidemic activity of an aqueous extract of boerhavia diffusa leaves in alloxan diabetic rats. Role of medicinal plants in the management of diabetes mellitus. Reduction in blood sugar could be seen from 7th day after continuous. The mechanisms of alloxan and streptozotocininduced diabetes.

Antidiabetic effect of morinda lucida stem bark extracts. The methanolic whole plant extract at high dose 500 mgkg exhibited significant anti hyperglycemic activity than whole plant extract at low dose 300 mgkg in diabetic rats. Available literature reveals that more than 400 plant species have been claimed to have anti hyperglycemic activity. Hyperlipidemia is an associated complication of diabetes mellitus. However, animal studies are promising there were no human studies conducted using boerhaavia diffusa. Effect of chronic administration of boerhaavia diffusa.

The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Antidiabetic activity in alloxaninduced diabetic rats fasting blood glucose fbg levels in normal rats were in the range of 95100 mgdl. Administration of ethanolic stem and leaves extract of coriander to alloxaninduced diabetic wistar rats at a. It has been successfully induced in a variety of animal species. Blood glucose levels and body weights of control and diabetic mice were monitored. Antidiabetic and antihyperlipidemic activity of roots of. The anhydrous derivative ocnhco 2 co is also known as well as a dimeric derivative. These are some of the earliest known organic compounds. Evaluation of insulin potentiating activity of ethanolic. Antihyperglycemic and antihyperlipidemic activity of. Alloxan has been noted to stimulate a type 1 form of diabetes when used in animals.